Fig. 3. Cognitive recovery assessments in neonatal mice with HI. Novel object recognition (NOR) was evaluated at both postnatal day (PND) 28 and 42. Linear Mixed Model was utilized to determine the impact of treatment on time spent with the novel object. There is an overall group interaction (F(3,16)=12.18, p=.0002). (A) NOR assessments at day 28 demonstrated HI+BDNF animals explored the novel object more than the familiar object when compared to HI+Saline animals (p=.0006). (B) At PND 42, NOR results demonstrated that HI+BDNF still interacted longer with the novel object compared to HI+Saline animals (p=.0426). The data is presented as ± standard dev. of the mean; n=5~6 per group. *p≤0.05, **p≤0.01, ***p≤.001.
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