The diagnostic processes for seronegative AIE
| Diagnostic criteria | Description |
|---|---|
| Clinical presentation | Rapid onset of working memory deficits, altered mental status, or psychiatric symptoms. |
| MRI | Potential abnormalities, especially in the medial temporal lobes. |
| CSF analysis | Elevated white cell count (pleocytosis) or increased protein concentration. |
| EEG | Abnormalities such as epileptic or slow-wave activity. |
| Absence of alternate causes | Ruling out other potential causes like infections, metabolic disturbances, or tumors. |
| Response to immune therapy | Supportive of diagnosis if there's a response to treatments like steroids, IVIG, or plasmapheresis. |
| Autoantibody status | Absence of specific neural autoantibodies in serum. |
IVIG, intravascular immunoglobulin therapy.